Endocrine Abstracts

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with multisystem involvement and varied presentation but its association with adrenal insufficiency is rarely reported.Case presentation: A 30-year-old female presented to the emergency department with fever, lethargy and syncopal episodes during the last 48 h. She complained of general weakness, abdominal pain, nausea, vomiting, weight loss and anorexia for five months. Symptoms det...

Background: Patients with type 2 diabetes (T2D) are at higher risk for thrombotic events and as a result cardiovascular disease. Platelet function may be used to assess prothrombotic state in patients with cardiovascular disease.Purpose: We aimed to investigate whether the administration of novel antidiabetic agents influence platelet function in TDM2 patients.Patients and Methods: We 60 enrolled consecutive patients with T2DM, on ...

Introduction: Patients with type 2 diabetes mellitus (T2DM) exert a higher risk for thrombotic events. Platelet reactivity may be used to assess prothrombotic state in such patients. The aim of this study was to investigate whether the administration of novel antidiabetic agents could influence the platelet reactivity in T2DM patients.Patients and methods: We enrolled 99 consecutive patients (males=63.3%), 64.92±8.3 years old, receiving metformin fo...

Objectives: This study aimed to assess the results of different perinatal nutritional patterns on skeletal development and insulin regulation of one-year-old Wistar rats.Methods: Three different diet regiments [Control Diet, (CD), food-restricted (FR), or fat-fed (FF)] were randomly provided to sixty-seven primigravid rats from the 12th till the 21st gestational date when they gave birth and throughout the 25-day lactation period. According to...

Background: Recent data is indicating that levels of circulating amyloid β 1-40 (αβ1-40), a proatherogenic aging peptide, may be considered as a novel biomarker in cardiovascular disease (CVD). Postmenopausal women represent a population with substantial unrecognized CVD-risk, which would benefit from identification of novel cardiovascular risk markers.Aim: To explore the role of plasma Aβ1-40 and its patterns of change over time in a...

Introduction: Emerging research in 3D-bone shape has provided new insights into the pathogenesis of osteoarthritis (OA). OA patients have increased subchondral bone area, associated with higher prevalence of cartilage loss. Higher B-score, a novel, machine learning-derived OA bone biomarker, is associated with increased OA symptom severity and structural progression. Arthropathy, despite being the commonest cause of morbidity amongst acromegaly patients, remains one of the und...

Background: Subspecialty tumor boards (TB) are uncommon and their benefit has not been clearly demonstrated for patients and providers alike. We tried to determine the decision patterns of a newly minted neuroendocrine neoplasm (NEN) tumor board (TB) and the factors behind those.Methods: We retrospectively reviewed all NEN TB recommendations from 07/2018 to 12/2021 and recorded patient characteristics, TB outcomes and associations between them.<p cla...

A 61-year-old woman was admitted to the Emergency Department with generalized seizures. She reported general malaise, anorexia, headache and multiple episodes of vomiting that started about 12 h before admission. She had a history of recent thyroidectomy, and she was on oral calcium carbonate (3 gr/day) and alpha calcidol (3 mg/day). Non-contrast head CT scan was negative for major findings. Laboratory work up revealed hypercalcemia (corrected calcium 14,4 mg/dl), renal impair...

Introduction: Patients with acromegaly have increased mortality, primarily related to cardiovascular/cerebrovascular disease. The objective of this study was to evaluate whether GH/IGF-1 excess increases vascular disease by adversely affecting fibrin network characteristics.Methods: In this case–control study, 40 patients with acromegaly (21 males, age 53±13 years, 45% disease remission) and 40 age and gender-matched controls were recruited. Cl...

Objective: Bleeding is one of the most dangerous complications following thyroid and parathyroid surgery. For this reason prophylactic perioperative thromboprophylaxis is not routinely use. The aim of this study is to investigate the incidence of clinical and subclinical deep vein thrombosis (DVT) and to validate the Caprini score as a predictive factor of high risk patients after these operations.Material and method: This is a prospective study involvin...